Metabolic Diseases

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Explora's senior management has decades of industry experience in cancer drug development. Our scientists routinely conduct contract research using xenograft models for industry as well as academic scientists. We also maintain rigorous cell culture procedures to ensure consistency in the quality of our cell lines.

Explora’s scientific team has extensive hands-on working experience in diabetes and obesity drug development. We can assist you with experiment design, animal model selection, study conduct, data analysis and report writing.

Explora’s research team has:

  • Hands-on experience with a variety of animal metabolic models
  • Extensive experience in diabetes and obesity drug development
  • Excellent technical and surgical capability
  • Established IACUC protocols

We can assist with:

  • Model selection and study design
  • In vivo drug screening
  • General technical report (GTR) generation for IND filing
  • On-site technical support and training
  • Explora Rodent Diabetes/Obesity Models

Genetic Models:

Many genetic changes can cause obesity and diabetic phenotypes. Several commercially available models are commonly used in diabetes/obesity research:

  • Zucker rat model
  • db/db mouse model
  • NOD mouse model
  • Other genetic models, such as Tubby

Non-Genetic Models:

Experimental procedures can be used to produce animals with obesity and diabetic phenotypes. The following models, which can be produced by Explora, are commonly used in diabetes research:

  • Diet induced obesity (DIO) model, which is a model for type II diabetes
  • STZ (streptozotocin) induced diabetic model, which is a model for type I diabetes

Assays and Endpoints

While many therapeutics have acute effects, others achieve their full effects after chronic treatment. Explora can help you design protocols that yield high-quality, meaningful data from every study. Common assays used in diabetes studies include:

In Vivo Assays for Glucose Metabolism

  • Resting Glucose levels
  • Glucose Tolerance Test (GTT)
  • Insulin Tolerance Test (ITT)

Additional Parameters

  • Clinical observations
  • Body weight
  • In-life collection of blood, serum, plasma, urine or feces for metabolite analysis
  • Necropsy with histopathology and immunostaining