Metabolic Diseases

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Explora’s scientific team has extensive hands-on working experience in diabetes and obesity drug development. We can assist you with experiment design, animal model selection, study conduct, data analysis and report writing.

Explora’s research team has:

  • Hands-on experience with a variety of animal metabolic models
  • Extensive experience in diabetes and obesity drug development
  • Excellent technical and surgical capability
  • Established IACUC protocols

We can assist with:

  • Model selection and study design
  • In vivo drug screening
  • General technical report (GTR) generation for IND filing
  • On-site technical support and training
  • Explora Rodent Diabetes/Obesity Models

Genetic Models:

Many genetic changes can cause obesity and diabetic phenotypes. Several commercially available models are commonly used in diabetes/obesity research:

  • Zucker rat model
  • db/db mouse model
  • NOD mouse model
  • Other genetic models, such as Tubby

Non-Genetic Models:

Experimental procedures can be used to produce animals with obesity and diabetic phenotypes. The following models, which can be produced by Explora, are commonly used in diabetes research:

  • Diet induced obesity (DIO) model, which is a model for type II diabetes
  • STZ (streptozotocin) induced diabetic model, which is a model for type I diabetes

Assays and Endpoints

While many therapeutics have acute effects, others achieve their full effects after chronic treatment. Explora can help you design protocols that yield high-quality, meaningful data from every study. Common assays used in diabetes studies include:

In Vivo Assays for Glucose Metabolism

  • Resting Glucose levels
  • Glucose Tolerance Test (GTT)
  • Insulin Tolerance Test (ITT)

Additional Parameters

  • Clinical observations
  • Body weight
  • In-life collection of blood, serum, plasma, urine or feces for metabolite analysis
  • Necropsy with histopathology and immunostaining