Diabetes

Explora's scientific team has extensive hands-on working experience in diabetes and obesity drug development. We can assist you with experiment design, animal model selection, study conduct, data analysis and report writing.

Explora's research team has:

• Hands-on experience with a variety of animal metabolic models
• Extensive experience in diabetes and obesity drug development
• Excellent technical and surgical capability
• Established IACUC protocols

We can assist with:

• Model selection and study design
• In vivo drug screening
• General technical report (GTR) generation for IND filing
• On-site technical support and training
• Explora Rodent Diabetes/Obesity Models

Genetic Models: Many genetic changes can cause obesity and diabetic phenotypes. Several commercially available models are commonly used in diabetes/obesity research:

• Zucker rat model
• db/db mouse model
• NOD mouse model
• Other genetic models, such as Tubby

Non-Genetic Models: Experimental procedures can be used to produce animals with obesity and diabetic phenotypes. The following models, which can be produced by Explora, are commonly used in diabetes research:

• Diet induced obesity (DIO) model, which is a model for type II diabetes
• STZ (streptozotocin) induced diabetic model, which is a model for type I diabetes

Assays and Endpoints

While many therapeutics have acute effects, others achieve their full effects after chronic treatment. Explora can help you design protocols that yield high-quality, meaningful data from every study. Common assays used in diabetes studies include:

In Vivo Assays for Glucose Metabolism

• Resting Glucose levels
• Glucose Tolerance Test (GTT)
• Insulin Tolerance Test (ITT)

Additional Parameters

• Clinical observations
• Body weight
• In-life collection of blood, serum, plasma, urine or feces for metabolite analysis
• Necropsy with histopathology and immunostaining

Contact us to find out how Explora can help you design meaningful experiments, contain costs, meet timelines, and achieve your preclinical research goals.