Metabolic Disease Research Services
Explora BioLabs’ scientists have extensive experience in diabetes and obesity drug development. We assist researchers with experiment design, animal model selection, study conduct, data analysis, and scientific report writing.
Proficiencies
Explora BioLabs’ research team has knowledge and hands-on experience with a variety of in vivo metabolic models and studies for diabetes and metabolic drug development.
- Model selection
- Study design
- In vivo drug screening
- Mechanistic studies
- Data collection and analysis
- Stringent IACUC oversight
- On site technical support and training
- Hematology
- Clinical chemistry
- Comprehensive tissue collection and processing
- Histopathology
- Flow cytometry
- Bioluminescence imaging
- And more
Animal Models
Experimental animal models that reproduce obese and diabetic phenotypes play a critical role in understanding both disease pathogenesis and its complications. Explora’s scientific experts have experience with genetic models commonly used in diabetes and obesity research, including:
Diabetes Models
Experimental procedures can be used to produce animals with obese and diabetic phenotypes. We provide the following common inducible diabetes models for in vivo pharmacology testing:
- Zucker rat
- db/db mouse
- NOD mouse
- Other genetic models (e.g., Tubby)
Diabetes Models
Experimental procedures can be used to produce animals with obese and diabetic phenotypes. We provide the following common inducible diabetes models for in vivo pharmacology testing:
- Diet-induced obesity (DIO) type II diabetes
- Streptozotocin (STZ)-induced type I diabetes
Testing Parameters
Experimental procedures can be used to produce animals with obese and diabetic phenotypes. We provide the following common inducible diabetes models for in vivo pharmacology testing:
Disease related biomarkers can also be assessed using clinical chemistry panels, complete blood counts, and lipid panels.
- Resting glucose levels
- Glucose-tolerance test (GTT)
- Insulin-tolerance test (ITT)
- Clinical observations
- Body weights
- In-life collection of blood, serum, plasma, urine, or feces for metabolite analysis
- Necropsy with histopathology and immunostaining
Disease related biomarkers can also be assessed using clinical chemistry panels, complete blood counts, and lipid panels.
Learn More
Download our Metabolic Disease Research Services brochure today, or contact us for more information.
Request a Study Quote
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