Metabolic Disease
Research Services

Explora BioLabs’ scientists have extensive experience in diabetes and obesity drug development. We assist researchers with experiment design, animal model selection, study conduct, data analysis, and scientific report writing.

Request a Study Quote

Proficiencies

Explora BioLabs’ research team has knowledge and hands-on experience with a variety of in vivo metabolic models and studies for diabetes and metabolic drug development.

  • Model selection
  • Study design
  • In vivo drug screening
  • Mechanistic studies
  • Data collection and analysis
  • Stringent IACUC oversight
  • On site technical support and training
  • Hematology
  • Clinical chemistry
  • Comprehensive tissue collection and processing
  • Histopathology
  • Flow cytometry
  • Bioluminescence imaging
  • And more

Animal Models​

Experimental animal models that reproduce obese and diabetic phenotypes play a critical role in understanding both disease pathogenesis and its complications. Explora’s scientific experts have experience with genetic models commonly used in diabetes and obesity research, including:
  • Zucker rat
  • db/db mouse
  • NOD mouse
  • Other genetic models (e.g., Tubby)

Diabetes Models
Experimental procedures can be used to produce animals with obese and diabetic phenotypes. We provide the following common inducible diabetes models for in vivo pharmacology testing:
  • Diet-induced obesity (DIO) type II diabetes
  • Streptozotocin (STZ)-induced type I diabetes

Testing Parameters

Experimental procedures can be used to produce animals with obese and diabetic phenotypes. We provide the following common inducible diabetes models for in vivo pharmacology testing:
  • Resting glucose levels
  • Glucose-tolerance test (GTT)
  • Insulin-tolerance test (ITT)
  • Clinical observations
  • Body weights
  • In-life collection of blood, serum, plasma, urine, or feces for metabolite analysis
  • Necropsy with histopathology and immunostaining

Disease related biomarkers can also be assessed using clinical chemistry panels, complete blood counts, and lipid panels.
Learn More 

Download our Metabolic Disease Research Services brochure today, or contact us for more information.

explora biolabs, cro, contract research, vivarium, preclinical research

Request a Study Quote

To request a study quote, please fill out our form.
Exciting News

Explora BioLabs Acquired by Charles River Laboratories, Inc.


Subscribe to Explora News

Please complete this form to create an account, receive email updates and much more.
Email  *
First Name *
Last Name *
Company Name *
*Required Fields
Note: It is our responsibility to protect your privacy and we guarantee that your data will be completely confidential.

"*" indicates required fields

Name*
This field is for validation purposes and should be left unchanged.

Request a Tour

"*" indicates required fields

Name*
This field is for validation purposes and should be left unchanged.