Metabolic Disease

Many genetic changes can cause obese and diabetic phenotypes, therefore, model choice can have an impact on study results and what can be measured. Explora’s scientific experts can help you choose models suited for your needs. We have extensive experience with several genetic models commonly used in diabetes/obesity research including:

  • Zucker rat
  • db/db mouse
  • NOD mouse
  • Other genetic models (ie., Tubby)

Additionally, experimental procedures can be used to produce animals with obese and diabetic phenotypes. We provide the following common inducible diabetes models for in vivo pharmacology testing:

  • Diet-induced obesity (DIO) type II diabetes
  • Streptozotocin (STZ)-induced type I diabetes

We have extensive experience in assays commonly used in metabolic disease studies, and we offer the following testing parameters:

  • Resting glucose levels
  • Glucose-tolerance test (GTT)
  • Insulin-tolerance test (ITT)
  • Clinical observations
  • Body weights
  • In-life collection of blood, serum, plasma, urine, or feces for metabolite analysis
  • Necropsy with histopathology and immunostaining
  • Disease related biomarkers can also be assessed using clinical chemistry panels, complete blood counts, and lipid panels