Cancer Xenograft Efficacy Models

Our in vivo oncology services include:

  • Subcutaneous xenograft models (human or murine cell lines)
  • Over 45 lines characterized in-house for tumorigenicity
  • Immuno-Oncology
    • Tumor re-challenge
  • Monotherapy, immunotherapy or combination therapy screening
  • Orthotopic tumor models (cells implanted directly into organs of interest)
    • Renal capsule, mammary fat pad (MFP), and spleen, prostate, ovarian, brain implantation
  • Utilize our commercial cell bank or customize with your own cell lines and PDX models
  • Tumorgenicity studies
  • Tumor bearing PK/PD studies
  • Metastatic models
    • Forced metastatic models
    • Spontaneous metastatic models
  • Humanized mouse models (hPBMCs or hCD34+)

Further Capabilities

  • Hematology
  • Clinical Chemistry
  • Comprehensive tissue collection and processing
  • Histopathology
  • Flow Cytometry

Available Cell Lines

Human Cell Lines

Melanoma

  • A375
  • MDA-MB-435
  • SK-Mel-1
  • SK-Mel-2
  • SK-Mel-24
  • SK-Mel-28

Myeloma

  • RPMI-8226

Ovarian Cancer

  • OVCAR3
  • SK-OV3

Pancreas Carcinoma

  • Bx-PC3
  • MIA PaCa-2
  • PANC-1

Breast Cancer

  • HCC1806
  • HS578T
  • MCF7
  • MDA-MB-231
  • MDA-MB-361
  • MDA-MB-436
  • MDA-MB-468
  • SK-BR3
  • ZR-75-1

Colon Cancer

  • Colo 205
  • HCT-116
  • KM12
  • KM12L4a
  • LS174T
  • SK-CO1

Renal Cancer

  • 786-0
  • A498
  • ACHN
  • Caki-1
  • Caki-2
  • KMRC1
  • SN12C

Liver Carcinoma

  • Hep3B

Lymphoma

  • NAMALWA
  • Raji

Lung

  • A549
  • NCI-H1993
  • NCI-H2122
  • NCI-H226
  • NCI-H292
  • NCI-H460
  • NCI-H522
  • NCI-H69

Head & Neck

  • KYSE-150

Glioblastoma

  • U-87 MG

Leukemia

  • MV-411

Prostate Cancer

  • LNCap
  • PC3

Sarcoma

  • A4573
  • HT-1080
  • SK-ES
  • TC-71

Murine Cell Lines

Sarcoma

  • A4573
  • SVR

Colon

  • CT26

Melanoma

  • B16F0
  • B16F10

Mammary

  • 4T1
  • Py8119
  • EMT-6

Lung

  • LLC